Learning objectives

• Prepare and dispense creams for external use
• Do so with correct methods (spatula on glass slab)
• Generate appropriate documentation and labelling
• Produce a product that is cleanly presented

Prescription

Rx Salicylic acid and sulphur cream aqueous APF
Mitte: 50g
Sig: Apply at night

D. Aman, MBBS

Batch Record

Name: Salicylic acid and sulphur cream aqueous APF 26
Batch Number: Discretionary

Preparation

1. Weigh out salicylic acid using non-metal spatula
2. On a glass slab, triturate the salicylic acid and sulphur with a small amount of aqueous cream to make a smooth paste
3. Gradually incorporate the remaining aqueous cream to make 50 g through doubling method
4. Ensure all contents are triturated/mixed well so that no flecks/spots are noticeable
5. Transfer the contents to a glass jar with a spatula
6. Tap the jar to ensure that the cream has settled to the bottom/smooth out the top of the cream [Never on the counter; tap on the palm gently]

Preservative and Container

Aq. cream contains 1 % w/w of phenoxyethanol (1 g phenoxyethanol in 100 g Aq. cream).

Since we're using 96 g of Aq. cream in 100 g total, we're using 0.96 % w/w phenoxyethanol.

Container: Amber or clear? Martindale suggests amber (EurPharm) but also other pharmacopoeias (CP, USP) don't. Justify your choice of container.

Label

Salicylic acid and sulphur cream aqueous APF 23/24
Apply the cream at night to the affected area

Preservative: 0.96% w/w Phenoxyethanol

STORE BELOW 25°C

Counselling

• Rx: Apply the cream at night to the affected area
• May stain the skin, hair and clothes
• Do not apply to broken skin
• Avoid contact with eyes and mucous membranes
• May be irritating

Corollary

• Suggested CALs: