PHR2021: Workshop 10

Learning Objectives

  • Get a feel of the coming workshop assessment
  • Solidify the understanding of modified release
PHR2021: Workshop 10

Name of the game

  • Part 1
    1. The circled number assigned to you on the table is your Scenario number
    2. Tackle the given scenario [40 minutes]
    3. Submit your work on Moodle submission point (pick 11AM)
  • Part 2
    4. Move to the bigger table number (e.g., TABLE ONE) that matches your scenario number
    5. Discuss/correct your work with the other students [30 minutes]
  • Part 3
    6. Move back to your original table
    7. Present your work to the rest of the table, 5 min each [30 minutes]
    8. Do peer assessment (link on Moodle) during each presentation.
PHR2021: Workshop 10

Scenario 1

Draw in vitro and in vivo release profiles for the following formulations:

  • Immediate release
  • Osmotic release
  • Delayed release (2 hr lag)
PHR2021: Workshop 10

Scenario 2

(Draw PEG)

PHR2021: Workshop 10

Scenario 3

Identify and draw the anticipated pharmacokinetic profiles resulting from oral administration of a stable, highly permeable drug with the provided in vitro release profiles, and include an immediate release version on the same graph.

  • Osmotic
  • Sustained
  • Enhanced (Could be lipid formulation)
  • Delayed/targeted
PHR2021: Workshop 10

Scenario 4

A patient with a hereditary hormonal disorder requires peptide replacement therapy. The current treatment regimen involves subcutaneous injections twice daily (bid).

Task:

  1. Draw the expected pharmacokinetic profile of this regimen over a one-week period.

  2. On a separate graph, draw the anticipated pharmacokinetic profiles following a SINGLE administration of this peptide via each of the following routes:

  • Transdermal patch
  • Pulmonary inhalation
  • Enteric-coated oral capsule
  • Intranasal spray
PHR2021: Workshop 10

Scenario 5

Eye drops are a common form of medicine for ocular infections. Re-sketch a simpliefied version of the diagram below from the Discovery material without the labels and draw/label it instead to illustrate the possible paths that drug may take after topical administration ofa solution to the front the eye.
gm

Refer to the main barriers to topical ocular delivery in this exercise. Where will most of the drug end up?

3. Based on your graph in task 2, identify which alternative route most closely resembles the pharmacokinetic profile of a single subcutaneous injection. Explain your reasoning using appropriate pharmacokinetic principles.